![]() The LGB is a 6-layered structure, innervated by optic tract fibers covering the contralateral visual field. Visual and auditory processing is encoded separately in the two major nuclei of the metathalamus, i.e., the lateral geniculate body (LGB) and the medial geniculate body (MGB). The human metathalamus, located caudoventrally of the main body of the thalamus, plays an important role in processing visual and auditory information. Furthermore, the high-resolution MGB BigBrain maps provide a basis for data integration, brain modeling and simulation to bridge the larger scale involvement of thalamocortical and local subcortical circuits. They can be linked to other 3D data of human brain organization and serve as an anatomical reference for diagnostic, prognostic and therapeutic neuroimaging studies of healthy brains and patients. The probabilistic maps were included into the Julich-Brain atlas, and are freely available. Probabilistic cytoarchitectonic maps in the MNI “Colin27” and MNI ICBM152 reference spaces were computed which reveal an overall low interindividual variability in topography and extent. The LGB and MGB were additionally identified in nine other postmortem brains. ![]() The maps were 3D-reconstructed to show the shape and extent of the MGB and its subdivisions with cellular precision. Three MGB subdivisions (MGBv, MGBd, MGBm) were identified on every 5th BigBrain section, and a deep-learning based tool was applied to map them on every remaining section. Therefore, histological sections of ten postmortem brains were studied. We therefore aim at providing cytoarchitectonic maps of the medial geniculate body (MGB) and its subdivisions in the BigBrain – a high-resolution 3D-reconstructed histological model of the human brain, as well as probabilistic cytoarchitectonic maps of the MGB and lateral geniculate body (LGB). Yet, detailed histological references of the microanatomy in 3D space are still missing. Understanding its layers and subdivisions is important to gain insights in its function as a subcortical relay station and involvement in various pathologies. The human metathalamus plays an important role in processing visual and auditory information.
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